What occurs to diffusion when dialyzer fibers become clogged?

When dialyzer fibers become clogged, the flow of the dialysate and blood is impeded, which negatively impacts the efficiency of the diffusion process. Diffusion relies on the movement of solutes from an area of higher concentration to an area of lower concentration across a semi-permeable membrane. In the context of hemodialysis, this membrane consists of the dialyzer fibers that facilitate the exchange of waste products and electrolytes.

As the fibers clog, there is less surface area available for this exchange to occur. The clogging can lead to a reduced gradient for the diffusion process, meaning that solutes may not move as easily through the membrane. Consequently, the overall rate of diffusion—how quickly and effectively substances move across the dialyzer—decreases. Thus, the correct choice reflects the understanding that any obstruction in the dialyzer fibers directly hampers the diffusion process, leading to a diminished ability to purify the blood.